Ketamine Withdrawal Symptoms, Timeline & Detox Treatment

Addiction Resource aims to provide only the most current, accurate information in regards to addiction and addiction treatment, which means we only reference the most credible sources available. To fatally overdose on ketamine alone, it would take approximately 6 to 10 times the amount used to help assist during surgical procedures. Ketamine is particularly dangerous when mixed with other substances such as alcohol, opioids, or tranquilizers, as it may lead to slowed breathing, decreased heart function, and coma. Falling into a k-hole usually only lasts a short period of time, but some people continue to feel disconnected from the world afterward and may exhibit ongoing signs of psychosis. Snorting ketamine may result in severe adverse side effects due to the lack of proper dosing. People who use ketamine recreationally will typically take the drug orally in pill form, or snorted in its white powder form.

Delayed Effects of Ketamine Use

  • Likewise, snorting and injecting ketamine are common ways to consume ketamine, so this permits quick entry into the bloodstream.
  • It has been shown that even after two or more unsuccessful antidepressant trials, the rate of remission in a subsequent trial is only 13% (3).
  • If you’re concerned about ketamine addiction, we’ll explore the signs of withdrawal, how ketamine abuse can happen, and treatment options.
  • Ketamine is a general anesthetic that doctors find useful in emergency room settings when performing procedures, such as reducing fractures and treating joint dislocations.
  • Plugging ketamine can result in unpredictable side effects, as it may be harder to measure the dose taken.

One of the most significant advantages of ketamine is its ability to induce anesthesia rapidly and reliably, making it particularly well-suited for use in emergency settings or during procedures where rapid onset is essential. Additionally, it induces minimal respiratory depression compared with older anesthetics. The week before Easter 2024, many of the world’s leading ketamine researchers gathered at the annual conference for ketamine and related compounds at the Blavatnik School of Government in Oxford. The first day ended with a debate about the suitability of at-home administration of ketamine for depression, preceded and followed by a vote from the audience. The vote before the debate was slightly opposed to using ketamine as a treatment for depression to be taken at home. However, after the exchange of expert opinions, the subsequent vote was slightly in favor.

  • When ketamine is abused, it distorts the senses, causing the user to experience strange sights and sounds.
  • A ketamine overdose can occur when the substances is taken in large amounts or when combined with other substances.

More on Substance Abuse and Addiction

It also forces us to stop and focus on the injury, preventing further damage. Someone on ketamine can incur a serious injury and continue on as if nothing happened, exacerbating the problem. Placebos are used in clinical trials because everyone tends to improve in a clinical trial regardless of treatment group assignment. To accurately isolate and measure the effect of the active treatment, outcomes need to be compared between groups to obtain valid information about the therapeutic potential of a treatment. Pain and depression can fuel more substance use in people with or at risk for substance use disorder (SUD), the clinical term for what is more colloquially referred to as addiction. The psychedelic and dissociative effects of ketamine can affect the prefrontal cortex and hippocampus.

Drugs, Sacraments or Medicine? Psychedelic Churches Blur the Line.

Ketamine is used for procedures that require short-term sedation or anesthesia and can be safely used in a wide age range, starting from 3 months. Children metabolize ketamine faster than adults, so higher dosing is required. Ketamine is highly effective for brief medical procedures that do not necessitate skeletal muscle relaxation and can be utilized as a pre-anesthetic for the induction of general anesthesia when combined with other general anesthetic agents.

  • People who misuse ketamine enjoy this state of detachment and often feel like they’re floating.
  • Ketamine’s unique psychoactive effects captivated certain segments of the population, particularly within the burgeoning rave and club scene.
  • Other substances ingested with ketamine include psychedelics such as PCP, LSD, and MDMA.
  • And perhaps most importantly, many patients are benefitting from the incredible healing potential of these medicines.

Drug Combination Effects

It was developed decades ago as a less toxic alternative to the drug phencyclidine (PCP), which was also developed as an anesthetic. A ketamine derivative, esketamine (under the brand name Spravato®), is approved by the U.S. Food and Drug Administration (FDA) for treatment-resistant depression in adults.

Is ketamine addictive?

The opioid withdrawal study (23) showed physiologic suppression of opiate withdrawal. The results from the ongoing naltrexone induction study should provide some insight as to whether ketamine improves opioid withdrawal symptoms independent from rapid opioid induction under general anesthesia. Future studies should assess and report on concurrent use of FDA-approved treatments for opioid use disorder (both at baseline and in the follow-up phase).

The “K-Hole” Experience

The amount of ketamine in Perry’s body likely caused him to lose consciousness. Ketamine is a general anesthetic that doctors find useful in emergency room settings when performing procedures, such as reducing fractures and treating joint dislocations. Seeking help for addiction may feel daunting or even scary, but several organizations can provide support.


They will emphasize that while under the effects of ketamine, you will learn to view drug use in a more negative light and sobriety in a more positive light. Studies have shown that people with alcohol or heroin addictions are less likely to relapse under ketamine therapy. All clinicians who administer ketamine should understand the indications and contraindications. The people who had cocaine addictions ketamine addiction got ketamine through an IV for 5 days, in addition to 5 weeks of mindfulness relapse prevention therapy. Ketamine, also known as Special K or Super K, is a short-acting anesthetic drug with hallucinogenic effects. It can change how you perceive sights and sounds, make you feel like you’re not in control, and make you feel detached from the world around you or any pain you’re feeling.

Will Ketamine Addiction Lead To Tolerance?

As moving through the initial — and often the most tumultuous — first three days of ketamine withdrawal, the journey takes a slightly different, albeit still challenging, turn. Psychological reliance can occur due to a number of reasons, from escapism to misinformation to underlying mental health issues — leading to serious health consequences. Ketamine, known to some as a horse tranquilizer and to others as a groundbreaking depression treatment, is a unique player in the world of drugs. Later, they would take a potent dose of psilocybin mushrooms, then smoke toxins from the Sonoran Desert toad, which brings on a brief altered state in which people often flail about, scream and sob. Gail Serruya, M.D., is a psychiatrist with years of training in psychotherapy, who recently founded Voyage Healing PC, a ketamine-assisted psychotherapy clinic in Philadelphia.

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